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Picking up right where we left off, Kaz and Oliver are trapped in the ER by an evil Skylar and the Annihilator. The two villains plan to take over the hospital, and eventually, the world.
Oliver and Kaz attempt to visit the Annihilator's lair to take his collection of superpowers and restore them to the superheroes, but they end up trapped in space. Meanwhile, Alan insists on attending his first Normo Halloween party.