In Islip, N.Y., Michael Symon digs into a decadent, 17-layer smokehouse reinvention of lasagna with pork, brisket, bacon and mac and cheese. Then in Buffalo, a brewpub takes the city's most famous export, buffalo chicken, and stuffs it into a scratch-made pierogi for an epic reinvention of the game day classic. Finally, a bicycle cafe in Pittsburgh slings some seriously tricked-out burgers for hungry riders.

In Sagaponack, N.Y., Michael Symon heads to a smokehouse where succulent, slow-smoked pork ribs are mopped with a tangy, citrus barbecue sauce. In Columbus, Ohio, a beefy burger topped with smoky kielbasa is a fusion of local flavors and an American classic. Finally, an Indianapolis restaurant serves up octopus-pork and salmon sausages in an insanely unique take on the tried-and-true hot dog.