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After flunking driver's education, Kim is visited by an artificially intelligent vehicle called Sadie whose creator Dr. Freeman has been kidnapped by Drakken to improve his army of robots.
When Dr. Director at Global Justice decides that it's the "Ron-ness" that's Kim's secret to success, Ron goes under the microscope. Unfortunately, this means being stolen by the lackey-intolerant Gemini, Dr. Director's older twin. Global Justice, Kim and Rufus take on Gemini's fist of fury (and Pepe the neurotic Chihuahua) to recover the Ron Factor.
Rufus poses as a Peruvian hairless show-dog so that Kim can investigate the mansion of a master jewel thief. Kim agrees to babysit Rufus while Ron is in France for a while. A series of events lead him to become the target of Shego, Duff Killigan, and Monkey Fist when he unknowingly swallows a microchip they're after.