Rufus poses as a Peruvian hairless show-dog so that Kim can investigate the mansion of a master jewel thief. Kim agrees to babysit Rufus while Ron is in France for a while. A series of events lead him to become the target of Shego, Duff Killigan, and Monkey Fist when he unknowingly swallows a microchip they're after.

Kim tries to skirt the old fashioned overprotectiveness of her elderly paternal grandmother ‘Nana' Possible during a visit to Florida while she unravels Drakken's latest mind-controlling plan.