Cesar and Andre help an amazing golden retriever named Fergus who survived a horrific burning. Fergus' owners hope that he can someday become a therapy dog for other burn survivors, but they need Cesar to help with the dog's behavior while on his leash.

Cesar Millan and his son, Andre, travel to San Francisco, California. The duo meet Pali, the founder and president of Rocket Dog Rescue, who canvasses local San Francisco shelters trying to find homes for dogs on the euthanasia list. Pali grew up homeless herself, so she identifies with these dogs that society has forgotten.