The first ladies of medicine are back and busier than ever. Simone and Toya's friendship is on the fence, but when Toya decides to throw a Halloween party to show off her new house, her husband Eugene insists she invites Simone to bury the hatchet. Quad is full speed ahead with her puppy couture line but when Quad learns Lisa Nicole ran a background check on her for "business" reasons, the two have a fall out. Meanwhile, Dr. Jackie's latest endeavor is to test out a lifestyle fitness program on the girls and hopefully everyone is willing to jump on board.

Trying to find the root of her anger, Jackie helps Simone understand how her dad's past transgressions are still affecting her life. As the ladies gather to celebrate Lisa Nicole and Heavenly's magazine cover, Simone comes face to face with Toya for the first time since their disagreement. Meanwhile, following a successful meeting with the private investigator, Quad receives all the information she needs to finally give Lisa Nicole a taste of her own medicine.