Pastor A.B. Schirmer loses his first wife in a fall down the stairs, then he loses his second wife in a car crash, causing investigators to ask whether the two tragedies are coincidental.

A case makes headlines when the defendant argues he was too obese to have committed murder.

A high-society hustler spins lies and practices deceit for decades, leading to an investigation during which cold case detectives retrace the steps of this charming con man to see if he was guilty of murder.

A woman from a small town moves to the big city of Las Vegas, where she finds a new career and a new love, then she vanishes, and her body is found within a few days, but discovering her killer will be a tougher mystery to crack.

Abducted in Ecuador, a young woman hatches a plan to escape using something hidden at the bottom of her bag.

After a woman disappears on a bone-chilling night, her husband provides a strange alibi, claiming he was camping at the time with their two young sons.

Landing a dream assignment, real estate agent Lindsay Buziak agrees to show a million-dollar home to a mystery couple, then she is stabbed to death at the opulent estate.

A Chicago Bears football player's relationship with a woman who is expecting their first child ends in tragedy.

When long-haul truck driver Lloyd Ford disappears, it doesn't raise many red flags, but two people know where he is and guard the secret for 27 years.

After model Paula Sladewski is found murdered, police study a few seconds of grainy video recorded during the last hours of her life to try to identify her killer.

A couple seems made for each other, but a secret is uncovered, and their passion turns into violence, then an elaborate plot is hatched to get revenge.

College student Heidi Allen vanishes from the convenience store where she works; Gary Thibodeau is convicted of Heidi's murder, but now another man has allegedly confessed to friends that he killed the young woman, blowing the case wide open.

A few weeks before Christmas, Jason Payne makes a frantic 911 call to report the shooting deaths of his wife and stepson.

Free spirit Brittany Tavar vanishes into thin air, and there is more than one suspect in her mysterious disappearance, including a handsome boarder and a friend turned enemy.

Matthew Podolak dies from antifreeze poisoning, and his death remains a mystery until his brother embarks on a quest for the truth.

After young father Matthew Podolak dies from antifreeze poisoning, the manner of his death remains undetermined until his brother embarks on a quest for the truth.

Businessman John Mimbela becomes convinced that Daniel Villegas' murder confession was forced and sets out to prove it.

In Aspen, Colo., socialite Nancy Pfister has a long list of friends, then she is found beaten to death in a closet of her Rocky Mountain home, Part 2 of 2.

In Aspen, Colo., socialite Nancy Pfister has a long list of friends, then she is found beaten to death in a closet of her Rocky Mountain home.

A fence triggers a deadly fight between neighbors, one of whom claims he shot and killed the other in self-defense; investigators study the victim's body to discern the truth.

Fun and pretty college student Corey Parker is working as a waitress in Jacksonville Beach, Fla., and she has plenty of admirers, then she is found stabbed to death in her apartment.

Intelligent, hard-working beauty Kathryn Laird lives life to the fullest, then her body is found in a river, and investigators must determine whether she took her own life or was the victim of foul play.