Meredith and Derek adjust to life at home with a newborn but find it difficulty being away from the hospital; Arizona tries to take steps to fix her broken marriage; Alex and Jo navigate through their new relationship; and Owen clashes with Jackson over financial issues at the hospital. Meanwhile, April anxiously awaits her boards results.

Meredith jumps back into work but finds it hard to excel at both motherhood and being a surgeon. Stephanie tries to make a good impression on Jackson's mom, and Jo finds herself overly involved with her new patient. Meanwhile, Callie and Owen deal with an emotional situation regarding a patient.