The doctors face the consequences of the events that took place at April's wedding. Meredith feels betrayed when Derek goes back on a promise, Alex is furious after returning to the hospital and hearing the news about his father, and Arizona and Callie decide whether or not to move forward together. Meanwhile, Bailey realizes she was wrong about the motive behind Ben's decision to move back to Seattle.

Arizona has a bad day which escalates when she advises one of Callie's patients on a potential double amputation. Derek goes back on a promise to Callie, and Jo and Stephanie come across an abandoned baby outside the hospital. Meanwhile, the doctors deal with the repercussions of the non-fraternization rule, which include meetings with HR and one doctor's suspension.