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As Derek prepares for his move to DC, Meredith keeps herself busy at the hospital. Meanwhile, Jackson and April deal with difficult news, and Arizona and Amelia discuss how to best approach Dr. Herman.
Maggie and Meredith disagree with Derek about the best way to approach a patient's case, which leads to a bigger argument between the couple. Meanwhile, Callie feels responsible when one of her veterans is pushed too far and one doctor's routine procedure results in a devastating diagnosis.
April stays optimistic as Arizona begins testing on her baby; Dr. Herman plans out a crash course in fetal surgery; and Owen and Callie encourage each other to get back into the dating scene. Meanwhile, Meredith, Maggie and Bailey use the 3D printer to gain a better understanding of their patient's tumor.
Primetime television's most riveting hour hits new heights as secrets of the past come to light and critical choices shape the future. Relationships are in turmoil as things between Callie and Arizon cool -- and Owen and Amelia's romance ignites. April and Jackson face a heartbreaking tragedy. Meanwhile, Meredith makes a stunning family discovery as opportunities pull Derek further away. And Maggie's shocking announcement proves that blood is thicker than water.