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Meredith is brutally attacked by a patient, and Penny is the one who discovers her. The doctors of Grey Sloan Memorial rush to stabilize Meredith and remain by her side in the harrowing aftermath.
As the rumor mill around the hospital continues to spiral out of control, Grey Sloan Memorial is flooded with injured firefighters from a nearby wildfire. Maggie struggles to keep things with Andrew professional at work; meanwhile, Jo questions Alex's priorities.
As the hospital deals with Meredith's trauma, Callie and Maggie perform a risky, experimental surgery on Alex's 15-year-old patient against his professional opinion. Meanwhile, Owen and Nathan are still at odds with each other, and Maggie and Andrew's relationship continues to develop.
Meredith struggles to deal with all her responsibilities after Amelia moves in with her, while Miranda begins life as the new Chief of Surgery.