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Bailey and April work to fix things between Richard and Catherine. Meanwhile, Eliza continues to pursue Arizona, and one of Alex's previous patients returns to Grey Sloan.
Meredith and Nathan have to confront their feelings when they are are stuck sitting next to each other on a plane.
April and Andrew consult with a fiery patient who has a giant, inoperable heart tumor. Meanwhile, Alex and Eliza are at odds over the treatment of a young patient, and Stephanie and Ben make decisions that could affect their careers.
After being on her own for some time, Meredith is beginning to explore the idea of a romance with Riggs. Unfortunately, Maggie desires him as well, which threatens to drive a bitter wedge between the sisters. At the same time, despite their differences, Jackson and April must come together when they are assigned a difficult case. Meanwhile, Alex faces the consequences of his vicious attack on DeLuca, Owen and Amelia's marriage implodes and a hospital-wide mutiny erupts when Bailey demotes Webber. Finally, Arizona may have found love again -- but is she sleeping with the enemy?