Seattle firefighters Ben Warren and Andy Herrera head to Grey Sloan after rescuing two boys that are injured in a house fire. With one of the boys' lives literally in Andy's hands, her skills are put to the test. Meanwhile, the doctors are hard at work on their projects for the Grey Sloan Surgical Innovation Contest; and Amelia brings Tom Koracick in to consult on her and Alex's patient.

Meredith tries to learn more about Marie Cerone's history with her mother. Meanwhile, Jo is applying for fellowships around the country and it throws Alex for a loop; and Tom Koracick helps April acknowledge her crisis of faith.