A patient gives Meredith some clarity on her dating situation around the holidays. The strain on Bailey and Ben's marriage comes to a head. Meanwhile, Betty drops a bomb on Owen and Amelia.

While Meredith breaks a hospital record, the rest of the doctors are sent scrambling in the wake of a massive overdose within the community. Meanwhile, Jackson wants to take a reluctant Maggie camping, and Levi and Nico's relationship continues to develop.