Catherine returns to Grey Sloan for a surgical case that makes Lucas and Blue queasy. Amelia treats a possible cancer patient with a family that's a little too supportive. Owen takes his medical future into his own hands, much to Teddy's surprise.

In the immediate aftermath of shocking events at the clinic, the hospital goes on lockdown and the Grey Sloan doctors split up to save multiple lives. Meanwhile, Maggie lands in hot water with Winston, and Jules' roommate makes a surprise appearance.