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Re-examine the personal and professional pressures of five eager, new doctors.
A boy needs a heart transplant but doesn't want it, and an argument over his treatment exposes philosophical differences between Burke and Cristina.
Izzie seems to be getting over Alex when she shares an undeniable chemistry with Denny Duquette, a patient who's awaiting a heart transplant.
Life gets even more intense for the doctors and interns of Seattle Grace hospital in year two as Meredith and Derek's relationship goes from complicated to downright insane with the arrival of Derek's wife, and Alex lets Izzie's obsession out of the bag.