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George and Izzie's romantic chemistry is put to the test, Mark develops a crush on a fellow surgeon, and Callie's role as Chief Resident is in jeopardy.
With his marriage in turmoil, the Chief turns to his fellow male surgeons for a "gentleman's evening," Cristina and Izzie heatedly compete for the same surgeries and the favor of the doctor performing them, Meredith treats the survivor of a skydiving accident, and the doctors treat two injured finalists who are competing in a promotional competition.
The ER is filled with teenagers after a schoolbus crash, Bailey treats a patient who was her high school crush, Derek goes out on a date with a fellow doctor, and Thatcher enters the ER looking for Meredith.
Life changes. Job changes. Love changes. Everything changes in Season 4. America'a favorite interns return as residents with many exciting, and sometimes frustrating, possibilities for their future. Featuring a passionate ensemble and some of the smartest dialogue on TV, Grey's Anatomy examines life thoroughly with great spirit and a whole lot of heart.