The Seattle Grace doctors are on edge when a new medical professional enters the hospital; Arizona struggles with the emotional and physical pain of a phantom limb; and while battling pregnancy hormones, an overly-emotional Meredith is confronted with her worst fear.

Competition heats up as several of the doctors fight to become the new face of Seattle Grace; April brings in an emergency case, and Jackson and Alex work with a transgender teen couple. Meanwhile, the hospital implements new policies which test the patience of the staff.