As the hospital continues to make positive changes under the new management, the doctors begin to realize that owning a hospital comes with its own set of problems and responsibilities. Meanwhile, Meredith worries about the wellbeing of her unborn baby, Callie and Arizona try to get the spark back in their relationship, and Alex gives Jo's new boyfriend a run for his money.

Upon receiving some unsettling news, Meredith and Derek take preventative steps for their children's future; a group of Syrian doctors arrive at Grey Sloan Memorial Hospital for a crash course in basic surgical skills that they plan to apply in the field; and April decides to come clean to Matthew regarding the truth about her virginity. Meanwhile, multiple pre-op patients develop infections, causing one doctor to wonder if she is at fault.