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Grey Sloan Memorial Hospital enters crisis mode as the storm rages, resources become scarce and patients flood in by the busload. Meanwhile, one of the doctors fights for their life.
The doctors of Grey Sloan Memorial Hospital prepare for a super storm heading towards Seattle; Owen's desire to be a parent gets stronger as he becomes closer to Ethan; and one wrong move puts the lives of Meredith and her baby in jeopardy. Meanwhile, Jo looks to Alex for help in a moment of crisis, and one doctor gets the shock of her life.
The plane crash changed everything. Now, with their futures unknown, the doctors of Seattle Grace must learn to adapt to changes, cope with losses and move forward with their relationships and careers.