After a Politician in Prague is framed for a murder, Red suspects it's the work of The Kingmaker - a strategist behind the rise of some of the world's most powerful politicians. While Red helps Liz and the FBI catch him, Liz uncovers a secret that Red's been keeping from her.

With the crashing of the mysterious prisoner transport plane, the city is on lock down as the authorities are on the hunt for all the escapees. Meanwhile, with Red in custody, Liz uses her power to get him out since he is their best chance at finding all the suspects. Elsewhere, their main objective is to track down Berlin, a prisoner on the plane who is somehow involved.