Ex-government agent and one of the FBI's Most Wanted fugitives, Raymond "Red" Reddington mysteriously turns himself in to the FBI and offers to give up everyone he has ever worked with including a long-thought-dead terrorist but under one condition - he'll only talk to newly-minted female FBI profiler, Elizabeth Keen with whom he seemingly has no connection. For Liz, it's going to be one hell of a first day on the job and what follows is a twisting series of events as the race to stop a terrorist begins.