While Cooper enlists Red on a case of personal importance, Ressler leads the Task Force on a mission to stop the resurgence of once dormant murder for hire ring. Determined to find answers, Tom disregards a warning to halt his investigation into the suitcase.

When Tom goes missing, Liz desperately retraces his steps in order to find him. Meanwhile Red's hunt for the suitcase of bones puts him on a collision course with Tom that will change everyone's lives forever.