Liz and the Task Force investigate an infamous assassin who has a long history of weaponizing diseases, but has now turned to even more insidious activities. Meanwhile, Red and Dembe travel to Cuba in search of a lead, and Aram considers a new relationship.

The Task Force investigates the unexplained disappearance and sudden re-emergence of a governor. Meanwhile, Red and Dembe surveil someone close to Katarina Rostova, as she inadvertently involves Agnes in an operation of her own.