John breaks the protocol of the Agent X Brotherhood to protect his former lover, Pamela Richardson, from members of a Washington D.C. based cabal intent on taking down the President. Meanwhile, Natalie, Malcolm and Judge Thorne work to unmask the members of the conspiracy.

A biological weapon is used in a failed assassination attempt on a high ranking government official. John, Natalie, and Malcolm investigate the case, and quickly find themselves racing the clock to stop a domestic terrorist group from deploying the virus on a greater, catastrophic scale.