Department of Justice Agent Lance Hamilton asks Sam for assistance in locating a former U.S. border patrol tactical officer who disappeared following a threat by the cartel. Also, Kensi and Army Criminal Investigative Department Special Agent Steve Evans partner on a dangerous mission to recover a stolen hard drive with sensitive military intelligence on it.

After Anna Kolcheck escapes from prison with her cellmate, Callen and the NCIS team assist with the investigation and search for her whereabouts.