Faced with multiple cases worldwide, the NCIS team splits up, with Callen and Sam working with Mossad Agent Eliana Sapir in Tel Aviv, and Kensi partnering with DOJ Agent Lance Hamilton in Los Angeles.

While Callen and Sam are aboard the USS Allegiance, the ship is placed under quarantine for possible Ebola exposure. Also, Kensi and Deeks investigate the murder of a petty officer who recently departed the USS Allegiance and is linked to the Ebola exposure.