D.J. Tanner-Fuller is a recently widowed mother to three boys. Going through this very difficult time for her, losing her husband and her kids losing their father, she seeks for the help of her best friend and neighbor since childhood Kimmy Gibbler, now raising a teenage daughter on her own, as well as her middle sister Stephanie, an aspiring singer who is always on the road.

When Stephanie, Kimmy and DJ have a girls' night out and leave Joey in charge of the kids, things get wild out on the town and at home.