After a fight with the Living Laser, Spider-Man meets Iron Man, a superhero he idolizes. Impressed by Spider-Man's scientific knowledge, Iron Man builds him a high-tech armor suit called the Iron Spider, which is equipped with an array of powerful weaponry. Despite lacking the necessary skills and having no control over the suit's functions, Spider-Man becomes increasingly smug about his new equipment, which puts a strain on his relationship with the team.

Spider-Man agrees to a video interview with aspiring news reporter Mary Jane Watson, but the interview is interrupted when the Incredible Hulk appears in Manhattan and goes on a destructive rampage. Mary Jane continues to film as Spider-Man tries to stop the Hulk. Unbeknownst to either of them, something much more dangerous is hiding out of sight and that something is called Zzzax.