Stan wants Steve to be popular and goes to desperate measures giving him steroids to make him bigger, better and part of the in-crowd at school. But when the steroids have an unexpected side effect, Steve gets a lot more attention than anyone expected. Meanwhile, after Haley makes a movie about Francine's life as a housewife, Francine is determined to start a new career as a doctor.

When Francine's birthday brings back haunting memories of a celebrity film moment stolen by George Clooney, Francine's new dream is to destroy the star. But when she tries to win Clooney's heart with the intention of breaking it, Stan actually falls for him and sabotages the plan. Meanwhile back at home, Roger builds a vineyard and starts up a private sweat shop of foster children.