A rare disease appears at Childrens Hospital, and the team has to journey into the buried remains of the original Childrens Hospital with Val's alter-ego, Derrick Childrens, to find the cure. Meanwhile. the rest of the doctors desperately try to save the hospital's landmark millionth patient.

Set four years ago, Nurse Beth's origins are uncovered as we explore the world of the Nurses' Quarters in the Childrens Hospital basement. Beth has to navigate the complex social hierarchy of the nurses and avoid losing their friendship when she suddenly gets promoted to doctor.