The gang finds out that Charlie may have cancer, so they hatch a plan to relieve his anguish. Meanwhile, Mac gets involved with a transvestite.

Four twentysomething friends run a struggling Irish pub in Philadelphia. In this episode, Mac and Dennis reach a new low when they pretend to be acquainted with a patron found dead in their bar in order to get closer to his granddaughter. Meanwhile, Dee visits her bedridden grandfather, and Charlie comes along for support.