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Chasing Leader through time to World War II, Hulk teams up with Captain America to stop Red Skull. In the present, the Agents of S.M.A.S.H. fight to free the world from Hydra.
Hulk follows Leader back in time to the Victorian era and unites the Howling Commandos against Dracula, who wants to shroud the Earth with Leader's gamma cloud, allowing vampires to prey night and day.
Finally catching up to Leader in the present, Hulk reunites with the Agents of S.M.A.S.H. However, he's unexpectedly whisked into the future by teenage Smashers who battle the Leader's threats.