On Halloween, the Agents of S.M.A.S.H. have to work with Nick Fury's Howling Commandos to prevent Dormammu from breaking into our dimension and turning all of humanity into Mindless Ones.

The Agents of S.M.A.S.H. team up with their old friends the Guardians of the Galaxy to stop the Skrulls from using the Hulks' gamma powers to create super-powered Skrulks!.