The Hulks discover the Leader stowed away on board the ship, but retribution must wait, as the Agents of S.M.A.S.H. have to fight Ronan the Accuser and his Kree soldiers to save an old foe: Ego the Living Planet. But when Galactus comes to consume Ego the Living Planet, the Agents of S.M.A.S.H. must put themselves at risk to save the lives of their two enemies.

On Halloween, the Agents of S.M.A.S.H. have to work with Nick Fury's Howling Commandos to prevent Dormammu from breaking into our dimension and turning all of humanity into Mindless Ones.