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Nurse Jenny Lee arrives at Nonnatus House in London's East End to begin her work as a midwife. Naive and unused to the harsh conditions of the borough, she must rise above her misgivings if she is to succeed in her new role.
A new midwife, Chummy Browne, arrives at Nonnatus House, and finds it difficult to prove herself. Meanwhile, Jenny befriends a young Irish prostitute who is expecting a baby, and is shocked by the Church's treatment of the girl.