Three iconic American storytellers have spent their lives chronicling the lives of others, while knowing almost nothing about their own family history. Ken Burns confronts the reality of his southern ancestors' role in the Civil War, including Confederate soldiers held captive and a slave-owning Virginian. Anderson Cooper, scion of one of America's most storied families, the Vanderbilts, longs to know more about his father's southern roots — including the story of an ancestor murdered by one his slaves. Anna Deavere Smith learns the story of her great-grandfather Basil Biggs, a free black man and former conductor on the Underground Railroad. All three guests' ancestors intersect at pivotal moments of American history.

Three celebrity chefs who cook the food of their ancestors discover family members who have shaped their lives — and America's cuisine. Tom Colicchio of "Top Chef" learns the hardships his family endured (famine, bandits) living in a tiny town in Northern Italy and celebrates the courage of his original immigrant ancestor, a man who crossed the Atlantic many times to bring the Colicchios to the United States; Ming Tsai, the child of immigrants who fled Mao's Cultural Revolution, was raised to believe that his that his family's Chinese past was obliterated by the Communists — instead, he finds that his roots can be traced back more than 2,000 years, yielding a large family tree; and Aaron Sanchez discovers that his family's treasured Mexican roots include people who were Spaniards, Africans and Native Americans.