Henry Louis Gates, Jr. uses DNA detective work to solve mysteries in the family trees of actor Téa Leoni, and radio host Joe Madison, introducing each of them to parents and grandparents whose names they've never heard before.

Henry Louis Gates, Jr. meets actors Scarlett Johansson and Lupita Nyong'o, and chef Lidia Bastianich — three women whose families crisscrossed the globe to escape oppression and find opportunity, leaving them with questions about their relatives who stayed behind.