Henry Louis Gates, Jr. explores the deep Mexican roots of talk show host Mario Lopez and comedian Melissa Villaseñor, uncovering ancestors stretching back to the 1500s. Weaving together stories of migratory farmers, Spanish Conquistadors and Native Americans, Gates conjures up personal histories of diverse, sometimes conflicting, elements.

Henry Louis Gates, Jr. helps John Leguizamo and Lena Waithe retrace the paths of their ancestors, uncovering crucial pieces of their own identities that were lost on the journey to America.