As the last remaining all-women's college in Oxford is bidding farewell to one of its most distinguished professors, murder rears its ugly head.

Student Amy Katz is murdered whilst taking part in a clinical trial for anti-depressant drugs, overseen by Dr. Alex Gansa, her psychiatrist following her soldier brother's death in Afghanistan. Amy captivated the other young male volunteers, including love-lorn Adam Douglas and Jack Collins - to the intense hatred of Jack's girlfriend Karen - but Amy was in love with the married Gansa. Several suspicious incidents cause Lewis to investigate the doctor.