Lieutenant Anita Van Buren is told by her doctor Valerie Knight (Deirdre O'Connell) that she came off her radiation just fine and her hemoglobin levels are up. She's set to go back to her doctor in three months to see if the tumor has shrunk. Meanwhile, Detectives Lupo and Bernard are called to a scene where four police officers were shot and killed, at a local pizzeria. With a room full of witnesses, they have a small description of the culprit but that's all. The case becomes even more confusing when they discover that the police officers may have known the shooter. The investigation quickly leads them to a drug cartel, a jealous husband, and a penitent judge who are all linked together. Tensions rise from both the homicide units, the DA's office, and even to the U.S. Attorney.

When the body of young model Brenna Lane (Sabina Gadecki) is found burning in an alley, Detectives Lupo and Bernard search for her killer. With no witnesses, the detectives must retrace the victim's last steps to get insight into her final days before her death. They quickly discover that just before her death, Brenna crashed an upscale political event, hosted by Senator Peterson (Tony Roberts) and his wife, Camille (Kathy Baker). As secrets unfold, Lupo and Bernard realize that they must untangle an intricate web of lies to obtain the truth about Brenna Lane's murder.