John is shocked when a woman arrives at his door, claiming that he is the father of her son, Wesley. 11 years ago she enlisted the service of "VitroChoice", a sperm bank that normally keeps the identity of the donors strictly confidential. She found out John's information by bribing a nurse and hacking into a government computer. John doesn't trust the situation and starts searching for an explanation.

John Does decides to go on a trip to London. He's struggling to calm himself down due to the claustrophobia caused by being on a plane when a Reverend dies. John finds out he was murdered (poisoned).He has to find the killer, who is on the plane, with a help of some people and others trying to make his job harder