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After Amanda wins an elite Medical Examiner's award, she, Mark, and Jesse have to investigate who deliberately let loose a deadly disease inside the upscale hotel where the award ceremony was going to take place.
Following the deaths of several patients and an unpopular doctor at Community General Hospital, Steve, Mark, and his colleagues work on trying to discover what connects all the deaths. When the doctors soon discover the connection to all the deaths – each victim previously survived a near death experience – they have to find out who the killer is before they carry out their next murder, and they have their sights set on Steve.