Jacob has reverted to being an alpha male and takes it upon himself to track down a dangerous drug dealer in Holby. With several patients suffering from the same symptoms, he skilfully persuades an unlikely person to comply.

Big Mac is more reliant on his painkillers than ever. He tries to get Zoe to write him another prescription, but to no avail. Starting to suffer from withdrawal symptoms and more desperate than ever for relief, Big Mac offers to help Robyn unpack the drugs delivery, and after a brief crisis of conscience, pockets a few packs.

Connor falls in a bin and hurts himself. He calls Max instead of Mercedes to help him. She is annoyed and suspicious, but Zoe steps up to defend him.

Big Mac's secret is getting on top of him and he's not the only one who's reached their limit today.

Painkillers are reported missing and suspected stolen. Big Mac's addiction is starting to affect his health. Mercedes threatens him to steal more drugs, but Big Mac eventually has to come clean to Noel and admit he has a problem. Noel is supportive and encourages him to go to an NA meeting, but will Big Mac bottle it last-minute?

Rita suspects Mark's stalking her when Charlie informs her that a number of complaints have been made against her. When she looks into it, the patients don't exist. She feels safe with Iain, but when she goes home she discovers her bedroom has been trashed, and she's terrified.

Jack has the day from hell and decides to leave to pursue his dreams in the travel industry.