The Johnsons welcome an African American family that has just moved into their mostly white neighborhood. Santamonica doesn't get along with the new neighbor's daughter, until she gives Santamonica attitude. Meanwhile, Rainbow is excited to celebrate her one-month anniversary with Bryce, but he tells her some devastating news.

Rainbow's friend Rebecca gets mono ("the kissing disease"), and after helping her out, she becomes interested in the medical field. Alicia fibs to Paul about getting a flu shot, and when Denise gets sick, their distrust of the medical community comes to light. Meanwhile, Johan and Santamonica go to live with Harrison while Denise is sick and start to enjoy his lavish lifestyle.