UFC Fight Night 75 is a Heavyweight Mixed Martial Arts Main event card between Josh "The Babyfaced Assassin" Barnett (33-7-0, 8KO's) fighting out of Fullerton, California going up against Roy "Big Country" Nelson (20-11-0, 14KO's) fighting out of Las Vegas, Nevada. This card is being broadcast live from the Saitama Super Arena in Saitama, Japan.

The scheduled undercard bouts are as follows:

Bantamweight: Norifumi Yamamoto vs. Matt Hobar

Bantamweight: Takeya Mizugaki vs. George Roop

Flyweight: Kyoji Horiguchi vs. Chico Camus

Middleweight: Gegard Mousasi vs. Uriah Hall

Welterweight: Kiichi Kunimoto vs. Li Jingliang