In the headliner, Ben Rothwell (36-9 MMA, 6-3 UFC), who's No. 4 in the USA TODAY Sports/MMAjunkie MMA heavyweight rankings, looks for his fifth straight victory when he takes on former titleholder and No. 8-ranked Junior dos Santos (17-4 MMA, 11-3 UFC). In the co-headliner, rising contender Derrick Lewis (14-4 MMA, 5-2 UFC) takes on former title challenger Gabriel Gonzaga (17-10 MMA, 12-9 UFC).

Rounding out the main card are heavyweights Curtis Blaydes (5-0 MMA, 0-0 UFC) vs. Francis Ngannou (6-1 MMA, 1-0 UFC), heavyweights Timothy Johnson (9-2 MMA, 1-1 UFC) vs. Marcin Tybura (13-1 MMA, 0-0 UFC), light heavyweights Igor Pokrajac (25-12 MMA, 4-7 UFC) vs. Jan Blachowicz (18-5 MMA, 1-2 UFC), and strawweights Maryna Moroz (6-1 MMA, 1-1 UFC) vs. Cristina Stanciu (5-0 MMA, 0-0 UFC).

Islam Makhachev vs. Drew Dober, lightweight bout; Santiago Ponzinibbio vs. Court McGee, welterweight bout; Raquel Pennington vs. Bethe Correia, women's bantamweight bout; Michael Chiesa vs. Beneil Dariush, lightweight bout is airing live from Amalie Arena in Tampa, Florida.