As Dr. Ethan Choi treats a bleeding teenage girl, he discovers she's just given birth, sparking a frantic search for her abandoned baby. When the details of the teen's troubled past emerge, Ethan finds himself at odds with pediatrician Dr. Natalie Manning and hospital administrator Sharon Goodwin as they're forced to make some difficult decisions about the teen's future. Dr. Will Halstead treats a hypochondriac with chest pains while struggling to navigate his overbearing wife. Meanwhile, med student Sarah Reese and psychiatrist Dr. Daniel Charles treat a patient suffering from dementia, only to discover she may not have dementia at all.

After shots ring out at a movie theater, the Chicago Med doctors work to treat the victims while hospital administrator Sharon Goodwin attempts to keep the press at bay. To treat a teenager with an eating disorder, Dr. Natalie Manning enlists the help of Dr. Daniel Charles, but his unorthodox methods rub Natalie and the teenage girl's mother the wrong way. Meanwhile, Nurse April Sexton, Dr. Will Halstead and Dr. Ethan Choi treat a racist patient whose strange form of bigotry surprises them all.