Dr. Rhodes and Dr. Choi disagree over the final decision made by a patient suffering from a life-threatening heart condition. The pending lawsuit against Dr. Halstead continues to move forward and Sarah Reese and Dr. Zanetti scramble to save a patient with a misdiagnosed flesh-eating bacterial disease. Elsewhere, Dr. Manning treats a young girl diagnosed with a contagious bacteria, prompting her and Dr. Halstead to take action to avoid a major outbreak.

Dr. Halstead and Sharon Goodwin deal with a husband intent on harvesting his recently deceased wife's eggs, but soon discover some vital information that surprises everyone. Dr. Charles is brought in by Dr. Choi to aid a patient who is trying to remove his own arm from his body because he feels like it doesn't belong. Nurse Sexton befriends the father of a child who is rushed into the hospital after swallowing magnets - a situation that Dr. Rhodes and Dr. Manning are concerned could present dangerous complications. Meanwhile, Sarah Reese finally learns about where she will do her residency, but has last-minute second thoughts