Wayne, wanting to please Nick, invents a Refuse Ingesting Protozoa or RIP that can eat anything. Jennings, who is being tracked by an environmentalist, puts toxic waste in Wayne's invention. RIP infected Quark, Quark infected the mail-man and so on. Now Wayne and family must stop these garbage-eating-zombies and get them to Jentech West where there is a high security system.

Ar'nox the alien, who was in "Honey, They Call Me The Space Cowboy", returns. This time he comes for a visit only to have his space ship stolen again. Now the Szalinski must get the space ship back, stolen from the so called "Men in Black".